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doi: 10.1172/jci38499 73 KikuchiHPinoMSZengMShirasawaSChungDC

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Targeted upregulation of pyruvate dehydrogenase kinase (PDK)-4 in slow-twitch skeletal muscle underlies the stable modification of the regulatory characteristics of PDK induced by high-fat feeding

Primary endpoint During the median follow-up of 20 months(ranging from 6 to 48 months), the incidence of MACEs was significantly lower in the GLP-1RA group (7.63%) compared to the control group (19.85%) (HR 0.444

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