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While the top of TM6 and ECL3 could not be confidently modelled for the exendin-4 complex, the portion of TM6 and TM7 that were modelled, along with the weak density corresponding to ECL3 supports a backbone conformation more similar to GLP-1 and oxyntomodulin bound receptors, rather than exendin-P5, albeit it is likely that this region is more conformationally dynamic

Calculating the "bias factor" from the relative potencies in these orthogonal assays provides a quantitative measure of the compound's signaling preference, offering a deeper mechanistic understanding of its action at the cellular level

Anesthesiology 125:133146 Zhang X, Liu S, MG P, Newport GD, Callicott R, Berridge MS, Apana SM, Jr SW, C W (2013) Protective effects of acetyl l-carnitine on inhalation anesthetic-induced neuronal damage in the nonhuman primate