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18 Description of Subjects Being Treated with Long-Acting GLP-1RAs in the Real-World Setting The efficacy of GLP-1RAs on glycemic and extra-glycemic targets observed in RCTs, and most importantly on reduction of cardiovascular events and overall mortality, have led scientific societies to modify clinical guidelines with recommendations towards an early use of GLP-1RA as second-line treatments, as an alternative or in combination with sodium/glucose cotransporter 2-inhibitors (SGLT-2i)

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