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Data availability The raw sequence data have been deposited in the Genome Sequence Archive 124 in National Genomics Data Center 125 , China National Center for Bioinformation/Beijing Institute of Genomics, Chinese Academy of Sciences (GSA: CRA032758 ( GSA-Human: HRA014470 ( that are publicly accessible at All data and materials presented in this manuscript are available from the corresponding author (H

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Clin Liver Dis 24:1123 Norman BH (2020) Drug induced liver injury (DILI)

Amino acid mutations in the H-site can significantly alter the catalytical activity of GST enzymes towards their substrates [88, 89]

The GSH tripeptide (- L-glutamyl-L-cysteinyl-glycine), the most abundant water-soluble non-protein thiol in the cell (110 mM) is fundamental for life by (a) sustaining the adequate redox cell signaling needed to maintain physiologic levels of oxidative stress fundamental to control life processes, and (b) limiting excessive oxidative stress that causes cell and tissue damage