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Because most plasma GSH originates in hepatocytes, the authors hypothesized that decreased plasma GSH also could signify intracellular depletion

These findings provide promising ideas for the treatment of neurodegenerative diseases

Pain 155 , 10271036 (2014)

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Clinical evidence includes stroke trials where 5 mg/day riboflavin, often in combination with other B vitamins, improved erythrocyte glutathione reductase activity and reduced the proportion of biochemically riboflavin-deficient patients, although clinical outcomes remain understudied (57)