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36 High levels of tumor necrosis factor- (TNF-), interleukin-6 (IL-6), and interleukin-1 (IL-1) induce a neuroinflammatory response in the brain

doi: 10.1038/ijo.2010.40

A pilot study subsequently conducted by Holst in collaboration with Mette Zander at Hvidovre Hospital between September 1999 and October 2000 indicated that continuous subcutaneous infusions of synthetic GLP-1 over 6 weeks into patients with quite severe type 2 diabetes dramatically improved their blood sugar control, lowered glycated haemoglobin levels and decreased their body weight

The NAD+ dosage is perhaps the biggest factor and for good reason

lack of trust in GPs