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None of them has undergone the kind of large-scale trials to establish safety and effectiveness that are required for FDA drug approvals

Ruminococcaceae UCG-004 was only present in the LD and WD control groups, with similar average relative abundances in both groups

And absent more rigorous studies, the team warned, it will remain difficult to convince the broader medical community that this so-called wonderful compound meets the criteria of a legitimate therapeutic agent. But it turns out, one group had begun to give it a go anyway