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After the pharmaceutical development program concluded in 2007, the accumulated safety dataset was submitted in support of a US FDA Generally Recognized as Safe (GRAS) determination for AOD9604 as a dietary ingredient

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Metabolic tracing studies further demonstrate that systemic NAD pools undergo inter-organ redistribution and are influenced by microbial metabolism and circulatory exchange [107, 108], indicating that NAD functions within a dynamic network rather than as a static intracellular reservoir [109]

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