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Concerns about liver toxicity were raised as early as 1977, when an FDA advisory panel said it was obligatory to add warning labels about liver damage

Other lipid-based systems (Jacob et al., 2025), such as solid lipid nanoparticles and nanostructured lipid carriers, enhance absorption and plasma retention of betulinic acid and andrographolide in various tumor models (Wang et al., 2024

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AgRP and NPY neurons are orexigenic (stimulate appetite) and are stimulated by signals like ghrelin, whereas POMC and CART neurons are anorexigenic (reduce appetite), and are activated by PYY and GLP-1

However, SSRIs often require weeks to take effect, are associated with significant side effects, fail to provide relief for approximately 40% of patients, and a significant portion of their efficacy appears attributable to the placebo effect [9, 10]