For diabetic retinopathy, GLP-1RAs are associated with the early worsening phenomenon linked to rapid glycemic control, a signal not typically observed with SGLT2 inhibitors, which generally show a neutral or modestly protective effect
Exercise, sleep quality, stress management, and proper supplementation all influence outcomes
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Common reasons to switch include a plateau on Wegovy 2.4 mg, tolerability issues, cost considerations as Wegovy gets more expensive at higher doses, or a change in goals or comorbidities
Longitudinal medical and pharmacy claims data in the Optum CDM are verified, adjudicated, adjusted, and deidentified and include information on patient demographics, inpatient and outpatient medical care, pharmacy dispensing, and outpatient laboratory test results from national laboratory vendors