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doi: 10.1172/jci.insight.97843 Summary Keywords obesity, high-fat, high-fructose diet, brown adipose tissue, type 2 diabetes mellitus, transcriptional analysis, semaglutide, tirzepatide Citation Ma T, Song F, Pan Y, He Y, Cao X, Zhang Y, Song G and Ren L (2025) Distinct effects of semaglutide and tirzepatide on metabolic and inflammatory gene expression in brown adipose tissue of mice fed a high-fat, high-fructose diet

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Others, like tirzepatide, also mimic GIP (glucose-dependent insulinotropic polypeptide) for additive effects