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Secondary prevention of CVD (adults) To reduce the risk of major adverse CV events (CV death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established CV disease and either obesity or overweight WEIGHT LOSS IN ADULTS RCT STEP 1 Study - Wegovy vs Placebo for Weight Loss in Adults Without Diabetes, NEJM (2021) [PubMed abstract] The STEP 1 study enrolled 1961 overweight or obese adults without diabetes Main inclusion criteria Age 18 years 1 failed attempt at dieting BMI 30 or 27 with one weight-related condition (e.g

The benchmark aims to limit long-term exposure to a level regulators say should reduce cancer risk to one in a million people

doi: 10.1080/26410397.2022.2044198

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Most probably all these fractions arise from 250 kDa protein with enzymatis or hydrolytic cleavage