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In a multi-generation reproduction study in rats, no impairment of fertility or other adverse reproductive effects were seen at doses up to 500 mg/kg (approximately 6 times the human dose in mg/m2)

For type 2 diabetes and reducing the risk of stroke or heart attack: For injection dosage form (Ozempic solution): Adults Initially, 0.25 milligrams injected under the skin in the thigh, abdomen, or upper arm as directed by your physician, once a week for 4 weeks

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This biased agonism refers to the fact that tirzepatide selectively engages cAMP signaling over -arrestin recruitment at the GLP-1R, which may augment cellular response via beneficial impact on GLP-1R cell surface trafficking, leading to increased cell surface expression