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Glutathione/glutathione disulfide (GSH/GSSG) ratio and Nicotinamide adenine dinucleotide phosphate NADPH/NADP+ ratio were measured using GSH/GSSG Assay Kit (S0053, Beyotime) and NADP/NADPH Quantification Kit (S0179, Beyotime) respectively

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"Nicotinamide N-Methyltransferase: More Than a Vitamin B3 Clearance Enzyme." Trends in Endocrinology & Metabolism

This process represents the summary of the GSH-related aspects with regards to: (i) changes in cellular GSH redox homeostasis through decreased GSH/GSSG ratio, due to either GSH oxidation or active GSH export in relation to the initiation or execution of the apoptotic cascade

& Ruoslahti, E