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Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

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Vitamin E inhibits the amplification of free radical reactions as an antioxidant that breaks down chains (45)

Spermidine increases the burning of fat and reduces its accumulation, improves insulin sensitivity, promotes gut health and reduces inflammation

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