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Evidence synthesis: We integrate RCT evidence on weight and metabolic outcomes with exploratory findings on reproductive outcomes, highlighting key effect modifiers (baseline obesity/IR phenotype, concomitant metformin, and follow-up window)

Beneficial Effects on Hormonal Balance (6 trials) These studies showed a variety of effects on hormone parameters including: Decrease in total androgen Decrease in total testosterone, free testosterone and dehydroepiandrosterone Increase in sex-hormone binding globulin (SHBG) Improved FSH/LH ratio and Induces ovulation by improving luteal phase progesterone production

At 26 weeks, both doses of dulaglutide were superior to insulin glargine in lowering HbA 1c

Engineered liver-targeted probiotic nanovesicles overcome oral absorption barriers to cure alcoholic liver disease

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