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Interestingly, the immunological phenomenon of original antigenic sin, where immune responses to subsequent similar but nonidentical antigens are dominated by less effective cross-reactive immunity rather than generating de novo highly specific and effective immunity, has been described for influenza

[DOI] [PubMed] [Google Scholar] 9.Zhuang C., Wang Y., Zhang Y., Xu N

Metformin can cross BBB and accumulate in some brain regions affecting various CNS functions by inhibiting neuronal apoptosis with promoting the neurogenesis process by activation of neuronal protein kinase C (PKC)

Because they address two different bottlenecks in tissue repair: BPC-157 is studied for blood flow and angiogenesis (the supply line), TB-500 for cell migration and actin dynamics (the repair crews mobility)

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