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While circulating levels of PYY 3-36 are frequently reduced in individuals with obesity 31,32,33,34,35 , these levels typically return to those detected in average-weight individuals following a reduction in body weight and/or gastric bypass surgery 32,33,35

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CART, cocaine- and amphetamine-regulated transcript

The appetite reduction causes patients to consume less food without experiencing hunger

Correlating the global signal with the time series of each voxel (Pearsons correlation) yields a whole-brain correlation, which is also considered a weighted form of functional connectivity density [42]