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GLP-1 side effects are often felt in the first few weeks of taking the drug or gradual dose increases, a process known as titration
This is the new kid, and the first dual-receptor incretin peptide to actually reach the market
In addition, other cell types, such as fibroblasts, play important roles in promoting tumor growth and metastasis, providing growth factors and contributing to extracellular matrix remodeling with matrix metalloproteinases [148, 149]
That analogy, imperfect as all analogies are, captures why comparing orforglipron with peptide agonists is worthwhile: the destination (GLP-1 receptor activation and its metabolic consequences) is shared, but the molecular route is so different that it changes the drugs absorption, its species reach, its signaling texture, and the very experiments needed to study it
Gartner, J
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