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To this aim, we measured the hydrogen peroxide (H 2 O 2 ) level by means of FOX assay and the superoxide (O 2 ) via immunofluorescence (IF)

The effect of GLP-1(736) in reducing CC-3, the Bax/Bcl-2 ratio and ROS generation was remarkably suppressed when ERK5 phosphorylation was inhibited by XMD8-92, indicating the essential role of ERK5/CREB in the antiapoptotic and antioxidative stress effects of GLP-1(736)

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Cells 4 , 520537 (2015)