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Connexin 43 in astrocytes helps maintain the BBB, and its loss causes continuous immune cell recruitment (69).Pericytes ensure endothelial integrity, regulating astrocytic endfeet, leukocyte trafficking, and vascular immune homeostasis and vasomotor (69, 70)

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To assess the importance of the VSMC GLP-1R for BP regulation in response to GLP-1R agonism, we treated normotensive Glp1r VSM+/+ and Glp1r VSM/ mice with semaglutide and recorded BP measurements

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