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Studies have also reported stimulation of proteoglycan and collagen synthesis in chondrocyte preparations, pointing to a meaningful role in joint research independent of its metabolic activity

This is important because chronic inflammation can worsen both hyperuricemia and gout severity

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However, with appropriate dose adjustment and consistent use, oral formulations can support meaningful clinical response for many patients

In summary, it is possible to produce clinical neuropathy in hens, but the doses required are far in excess of the LD 50