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In CRC, combining 5FU with DNA-damaging agents oxaliplatin and/or irinotecan was an empirical choice rather than a rationally designed strategy, and no new combination partners have been added since the introduction of the biological EGFR and VEGF-targeting agents in the early 2000s
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Western blot and real-time PCR results revealed that ACE downregulated not only GPX4 expression but also its mRNA levels (Fig
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