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In much of the literature, TB-500 refers specifically to the ~17-amino-acid fragment containing the LKKTETQ actin-binding motif the minimal sequence responsible for T4s cytoskeletal activity

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IRE1 binding with tumor necrosis factor receptor-associated factor 2 (TRAF2) activates IKK and JNK1, thus promoting chronic inflammation in IR 37,58,59 (Fig