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Some people with excess fat mass also have low muscle mass and these individuals may not be able to afford the loss of muscle mass

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discontinue use if you become pregnant, as it is not recommended during pregnancy or breastfeeding

This is a head-to-head comparison, and [orforglipron] is certainly quite effective. According to the treatment-regimen estimand, weight loss at 1 year was 6.1% with orforglipron 12 mg, 8.2% with orforglipron 36 mg, 3.9% with oral semaglutide 7 mg and 5.3% with oral semaglutide 14 mg

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