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While GLP-1 RAs have provided an important new weapon for those suffering from profound obesity, they unfortunately trigger the same counter-productive mechanisms as other weight-loss efforts, which rely on caloric restriction, resulting in muscle loss, which limits the fat loss and metabolic benefit

Evolution of sarcopenia status and risk of incident cardiovascular disease

Tirzepatide is FDA-approved for the treatment of Type 2 diabetes(Mounjaro) and chronic weight management (Zepbound)

Store Rybelsus in its original blister packaging at room temperature below 30C, protected from moisture, and never transfer tablets to pill organisers as this compromises stability

This was relaxed in 2016 to allow metformin use to a GFR 30, but still not allowing initiation below 45, and insisting on stopping at GFR 30