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However, numerous studies indicate that individuals with ME/CFS experience increased intestinal permeability, supporting the theory that Gram-negative bacterial endotoxins, also known as LPS, may enter the mesenteric lymph nodes and the blood stream through the loosening of tight-junction proteins (e.g., Zonulin), triggering an immune response and resulting in systemic inflammation [10, 21, 24, 39,40,41,42]

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Esta accin tiene un impacto sistmico, ya que al prevenir el paso de macromolculas al torrente sanguneo, reduce la inflamacin sistmica de bajo grado , a menudo manifestada como dolor articular y niebla mental

This space contains blood vessels and lymphatic channels that absorb the peptide into circulation while also allowing some local tissue effects