basal insulin plus glp 1 Consensus on treatment in type 2 diabetes Insulin and GLP-1-dependent intracellular signal

doi: 10.1002/bdrc.20101 65 ReiterRJTanDXKorkmazARosales-CorralSA

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Taken together, the increased effect of simultaneous GIPR and GLP-1R agonism relative to GLP-1R monoagonism on AgRP neuron dynamics aligns with mounting evidence for the superior efficacy of combined GIP and GLP-1R activation for the treatment of obesity (2528), and may represent a partial mechanism for the remarkable weight loss induced by dual incretin agonism

PubMed Wchter S, Vogt M, Kreis R, Boesch C, Bigler P, Hoppeler H, Krhenbhl S

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