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Furthermore, in rat pheochromocytoma PC12 cells, senkyunolide H prevented the loss of mitochondrial membrane potential (MMP) and suppressed the rise in ROS induced by the neurotoxin 1-methyl-4-phenylpyridinium

GLP-1 RAs, however, work to suppress glucagon secretion to reduce blood glucose levels

Sowa-Staszczak et al., 2016

However, the upregulation of SIRT6 inhibits the transcription of Notch1 and Notch4 through deacetylating H3K9 and significantly downregulates the secretion of NLRP3 and the pro-inflammatory factor IL-1, thereby alleviating the inflammatory response, mitigating podocyte damage and glomerulosclerosis (Liu et al., 2017

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