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Kruppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis

Some debate exists about long-term use since obesity tends to be chronic, these medications likely need to be continued to maintain weight loss (as stopping leads to regain, based on observations)

Dehydration was the AE with the highest number of reports for severe outcomes of GLP-1RAs, including liraglutide (n = 318, 23.93%), dulaglutide (n = 434, 20.90%), semaglutide (n = 370, 25.10%), tirzepatide (n = 70, 32.86%)

Craft, C

The majority of retrospective analyses also support this concept