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A recent study also demonstrated mislocalization of APE1 from the nucleus to the cytoplasm as a possible trigger of oxidative DNA damage in spinal motor neurons expressing mutant SOD1 G93A , despite upregulation of multiple DNA repair enzymes, suggesting that restricted localization of APE1 could inhibit redox homeostasis (Li J
Glutathione is a powerful antioxidant that is crucial to almost all body functions
Christian Bernecker, Luisa Lenz, Martin S
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However, as doses reach higher thresholds, such as two or three grams, the risk of liver enzyme elevation increases, especially when combined with alcohol
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