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Importantly: Neither peptide is FDA-approved for human use There are no large-scale human clinical trials validating safety or efficacy Quality and purity are often uncertain when purchased through underground or non-medical sources Despite this, BPC-157 and TB-500 are popular in bodybuilding, CrossFit, and athletic recovery spaces because of claims around faster healing and reduced downtime from injuries

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PMID: 27532814

Specifically, eligible studies included participants (P) with a confirmed diagnosis of vitamin B12 deficiency, interventions (I) involving oral or sublingual vitamin B12 administration, comparators (C) using intramuscular supplementation, and outcomes (O) reporting changes in serum vitamin B12 or homocysteine levels

Nausea, vomiting and digestive complaints arise from the slowed gastric emptying and the strengthened satiety signal