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Limitations include limited demographic diversity (predominantly White and male participants) and the non-causal, post-randomization nature of analyses linking adiposity change to outcomes, which precludes definitive mechanistic inference and may limit generalisability to more diverse populations

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Platforms integrating ceramide resupply through lipid nanoparticles, barrier strengthening based on antioxidant extracts, and re-epithelialization and mechanical signal inhibition have shown that barrier restoration is a feasible starting point for microenvironmental reprogramming