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Specific numbers from animal studies include: reported upregulation of growth hormone receptor expression in tendon fibroblasts, effects on VEGF-mediated tube formation in endothelial cell assays, and dose-dependent reductions in gastric ulcer area in rat models at doses ranging from 10 micrograms per kilogram to higher concentrations

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Preclinical research is extensive, with over 35 published animal studies showing benefits for tendon, ligament, muscle, and gut healing