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MHRA chief safety office Dr Alison Cave told the BBC: Patient safety is our top priority and no medicine would be approved unless it met our expected standards of safety, quality and effectiveness

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Notably, -synuclein aggregation has been detected in the enteric nervous system (ENS) prior to CNS involvement in a subset of patients, suggesting a potential gut-to-brain propagation pathwaythough this remains controversial and may represent independent parallel processes rather than sequential spread