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Transcriptome profiling of human post-mortem tissues (obtained from people aged between 16 and 102 years) found prominent and complex changes in gene expression in oligodendrocytes and astrocytes, whereas the neuronal transcriptome remained more or less undisturbed

Adding GIP receptor activation might further support these properties, suggesting that Tirzepatide might play a significant role in lipid regulation

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For instance, where enzymes like CHAC1 exhibit a helical conformation in this region, CHAC2 has a flexible loop

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