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This selectivity profile is central to the ipamorelin vs sermorelin research conversation

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These medications are prescribed for chronic weight management in adults who have obesity or those who are overweight with a co-morbidity, like high blood pressure or high cholesterol

Excessive glutamate signaling can induce neuronal dysfunction and cell death through the production of excitotoxicity, a process characterized by a large influx of calcium, which results in a cascade of events involving the disruption of calcium-dependent cellular pathways, mitochondrial dysfunction, the production of oxidative stress, and the activation of apoptosis