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For this reason, drugs with a long half-life (e.g., amiodarone, elimination t 1/2 of about 58 days) are usually started with a loading dose to achieve their desired clinical effect more quickly

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RYBELSUS and OZEMPIC tablets are contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) [see Contraindications (4)]

Furthermore, Lau et al

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