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The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice

In over a decade of GLP-1 medications being commonly prescribed, security issues with injectable medications are vanishingly rare

Together, these trials enroll thousands of participants across dozens of countries, providing the comprehensive efficacy and safety dataset required for regulatory approval in obesity

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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT) developed at the University of Texas Medical Branch by Neelakantan and colleagues as part of a medicinal-chemistry program targeting NNMT for metabolic-disease research