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doi: 10.1016/j.immuni.2006.03.011 159 KawabuchiMSatomiYTakaoTShimonishiYNadaSNagaiKet al

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In any case, the structure of the Co II -bound NiCo riboswitch reveals four Co II binding sites that likely nucleate formation of a four-way junction stabilized by a network of contacts that may explain how cooperative binding of Co II ions to adjacent sites might be achieved (Figure 22D)