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Mild Tolerance Reactions & Strict Contraindications Mild Tolerance Reactions: Temporary injection site redness, mild headache, transient fatigue, mild gastrointestinal discomfort (usually subsides within 1-3 days) Strict Contraindications: Active malignancy, pregnancy/lactation, coagulation disorders, anticoagulant users, minors 7

Phospholipid liposomes, ethosomes, and penetration enhancers (such as propylene glycol or oleic acid at low concentrations) improve dermal delivery

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