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Ongoing studies in both human and animal models continue to clarify its dual protective and pathological roles, while future research will determine whether modulating TNF- or its receptors represents a viable therapeutic strategy in AD

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Likewise, there is greater proliferation of human umbilical vein endothelial cells (HUVECs), significantly promoted migration of HUVECs (transwell assay), and the upregulated expression of VEGF-a, and accelerated vascular tube formation in vitro (Huang et al., 2015)

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