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However, its benefit is mainly dependent on adherence, which remains suboptimal in many patients due to discomfort and inconvenience, with adherence rates often falling below 50% in routine clinical practice [22]

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The glucoregulatory and anorectic properties of GLP-1 action are conserved in humans, including people with type 2 diabetes (T2D), supporting pharmaceutical development of multiple degradation-resistant short and long-acting GLP-1Rs for the treatment of T2D [2]

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