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doi: 10.1152/ajpcell.00600.2006
doi: 10.1124/jpet.111.182220
Contraindications: Pregnancy and lactation without prior specialist consultation
Poor prognostic factors for melasma treatment include: Fitzpatrick skin types IIIV genetic and familial predisposition long-standing disease 2 years persisting despite treatment history of procedural interventions (eg lasers, microneedling) history of treatment by 2 physicians (possibly suggesting long duration and recalcitrant disease) long-term self-treatment with topical steroids ochronosis from hydroquinone use either long term or high strength mixed-type melasma
Oxidative stress and depletion of cellular GSH are considered key factors in the onset and progression of various chronic and age-related disorders
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