The core features include the depletion of beneficial bacteria that produce short-chain fatty acids (SCFAs) (such as Lachnospiraceae and Ruminococcaceae) and the enrichment of potential pathogens with pro-inflammatory potential (such as Enterobacteriaceae and Streptococcaceae)
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Histamine : Causes blood vessel dilation, increased mucus production, and itching Prostaglandins (particularly PGD2) : Contribute to inflammation in airways Leukotrienes : Potent contributors to airway constriction (LTC4, LTD4, LTE4) Cytokines : Signal other immune cells to join the response (IL-4, IL-5, IL-6, IL-13) Tryptase : Promotes inflammation and tissue remodeling This is why blocking just one pathway like antihistamines do often isn't enough
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Some people may experience symptoms like nausea, vomiting, diarrhea, or constipation when taking the medication