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As drug shortages end, compounded versions might become harder to get

And while our skin does have what are called viscoelastic properties, which allow it to recoil to a certain extent after being stretched, with significant weight loss, there inevitably is more excess skin than can retract, says Burns

Additionally, regulatory monitoring has identified safety concerns, including nearly 400 reported pancreatitis cases, with over 100 cases recorded in 2025 alone

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This is why compounded tirzepatide users often prefer gentler escalation schedules