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This work was supported by the Science and Technology Plan Projects of Zhenjiang (SH2023078), the Medical Education Collaborative Innovation Fund of Jiangsu University (JDYY2023009) and the National Natural Science Foundation of China (32002235)

It is called a beyond-use date, or BUD, and understanding the distinction could save you from using degraded medication or throwing away perfectly good tirzepatide prematurely

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To examine the capacity of WT and Mda5 -/- HSCs to repopulate lethally irradiated recipients, we sorted and transplanted 100 LSK-SLAM HSCs from young or aged WT or Mda5 -/- mice together with aged-matched CD45.1 competitors into CD45.1 lethally irradiated recipients, followed by whole bone marrow competitive secondary transplantations

This reduction in glutathione levels is associated with increased susceptibility to oxidative stress and age-related health issues