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There are several reasons GLP-1 drugs might make you feel more tired than usual

Starting at 250 mcg (or lower in sensitive individuals) rather than the traditional 500 mcg "standard dose" from research literature reduces nausea substantially while still establishing the tanning response over a longer loading period

Miyata Y, Mukae Y, Harada J, Matsuda T, Mitsunari K, Matsuo T, Ohba K, Sakai H

[76] [77] activation of TAAR1 may restore impaired dopaminergic signaling in the prefrontal cortex and thereby correct deficits in inhibitory control associated with binge eating behaviors

Therapies currently being considered include antivirals like valganciclovir, a guanosine analog with potent anti-human herpesvirus activity, including in vitro and in vivo activity against the lytic phase of EBV that can reduce mucosal shedding of EBV during treatment (127)