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Combined inhibition of class 1-PI3K-alpha and delta isoforms causes senolysis by inducing p21WAF1/CIP1 proteasomal degradation in senescent cells

Dado que la semaglutida manda seales de saciedad al cerebro, estudiaron los genes involucrados en este proceso en personas con una mayor respuesta a la prdida de peso tras el uso de Ozempic y personas con menor respuesta de lo esperado

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Cancer Res 63 : 627635 Sciacca L, Mineo R, Pandini G, Murabito A, Vigneri R, Belfiore A (2002) In IGF-I receptor-deficient leiomyosarcoma cells autocrine IGF-II induces cell invasion and protection from apoptosis via the insulin receptor isoform A

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