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Likewise, restraint stress rapidly modulated KP enzyme expression in rats, with amygdala IDO increasing within 1 h, amygdala KMO and kynureninase rising by 4 h, hippocampal TDO decreasing within 4 h, hypothalamic TDO upregulated at 4 h, and medial prefrontal cortex kynureninase reduced shortly after stress with effects lasting at least 24 h [70]

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doi: 10.1016/j.jpba.2016.12.037 117 LinghangQYiyiXGuoshengCKangXJiyuanTXiongLet al

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While more research is needed in this area, a study looking at GLP1 receptor agonist use and opioid overdose risk in patients with type 2 diabetes and opioid use disorder (OUD) found that semaglutide was associated with reduced opioid overdose risk in patients with comorbid T2D and OUD